Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, and expression in COS-1 cells with adrenodoxin resulting in significantly more pregnenolone, co-expression with the steroidogenic acute regulatory protein and a human P450scc/adrenodoxin reductase/adrenodoxin fusion constructs. COS-1 cells transfected with a modified construct in which human P450scc is replaced by Dasyatis sabina P450scc show higher rates than cells transfected with Dasyatis sabina P450scc alone. Suncloning in Escherichia coli strain DH5alpha | Hypanus sabinus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hypanus sabinus | D0EFX3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
interrenal gland | - |
Hypanus sabinus | - |
Synonyms | Comment | Organism |
---|---|---|
cytochrome P450 cholesterol side chain cleavage | - |
Hypanus sabinus |
P450scc | - |
Hypanus sabinus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme shows steroidogenic activity. The stress peptide adrenocorticotropic hormone, ACTH, elicits its effects on corticosteroidogenesis in part through regulation of StAR and P450scc mRNAs. Chronic ACTH-induced glucocorticoid synthesis in elasmobranchs is mediated by regulation of primary steroidogenic mRNAs | Hypanus sabinus |