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Literature summary for 1.14.15.6 extracted from

  • Tuckey, R.C.; Li, W.; Zjawiony, J.K.; Zmijewski, M.A.; Nguyen, M.N.; Sweatman, T.; Miller, D.; Slominski, A.
    Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc (2008), FEBS J., 275, 2585-2596.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.15.6

Application

Application Comment Organism
drug development the vitamin D3 derivatives produced by the action of P450scc are good candidates for use in the therapy of hyperproliferative disorders Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
20,23-dihydroxyvitamin D3 + reduced adrenodoxin + O2
-
 Bos taurus 17alpha,20,23-trihydroxyvitamin D3 + oxidized adrenodoxin + H2O
-
 ?
20-hydroxyvitamin D3 + reduced adrenodoxin + O2
-
 Bos taurus 20,23-dihydroxyvitamin D3 + 17alpha,20,23-trihydroxyvitamin D3 + oxidized adrenodoxin + H2O
-
 ?
vitamin D3 + reduced adrenodoxin + O2
-
 Bos taurus 20-hydroxyvitamin D3 + oxidized adrenodoxin + H2O when incubated in 0.45% cyclodextrin, 20-hydroxyvitamin D3 is the major product of vitamin D3 metabolism by P450scc. The second major product is 20,23-dihydroxyvitamin D3. Major products dissociate from the P450scc active site and accumulate at a concentration well above the P450scc concentration ?

Synonyms

Synonyms Comment Organism
CYP11A1
-
 Bos taurus
cytochrome P450scc
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
adrenodoxin
-
 Bos taurus