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Literature summary for 1.14.15.6 extracted from

  • Arukwe, A.
    Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc)-regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish (2008), Cell Biol. Toxicol., 24, 527-540.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
Salmo salar 5743
-

Organism

Organism UniProt Comment Textmining
Gadus morhua
-
-
-
Oncorhynchus mykiss
-
-
-
Salmo salar
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Salmo salar
-
gonad
-
Salmo salar
-
interrenal cell
-
Salmo salar
-
intestine
-
Oncorhynchus mykiss
-
kidney
-
Salmo salar
-
kidney trunk Oncorhynchus mykiss
-
liver
-
Salmo salar
-
oocyte
-
Gadus morhua
-
oocyte follicular cell, oocyte membrane Salmo salar
-
pyloric cecum
-
Oncorhynchus mykiss
-
spleen
-
Oncorhynchus mykiss
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + reduced adrenodoxin + O2
-
Salmo salar pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O
-
?

Synonyms

Synonyms Comment Organism
cytochrome P450-mediated side-chain cleavage enzyme
-
Oncorhynchus mykiss
cytochrome P450-mediated side-chain cleavage enzyme
-
Gadus morhua
cytochrome P450-mediated side-chain cleavage enzyme
-
Salmo salar
P450scc
-
Oncorhynchus mykiss
P450scc
-
Gadus morhua
P450scc
-
Salmo salar

Expression

Organism Comment Expression
Gadus morhua 14 days exposure of previtellogenic ovarian oocytes to nonylphenol produces a unique and consistent concentration-specific pattern of modulation of StAR and P450scc gene expression, increasing from 0 (control) to 1 and 10 micromol, and decreasing at 50 and 100 micromol up
Oncorhynchus mykiss expression of StAR and P450scc transcripts in non-steroidogenic tissues up
Salmo salar relationship between cortisol production and induction of transcription of steroidogenic acute regulatory (StAR) protein and P450scc. Exposure of juveniles to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and the synthetic estrogen 17alpha-ethynylestradiol produces transcriptional modulations of StAR and P450scc expression in interrenal tissue. In juvenile salmon exposed to 17alpha-ethynylestradiol, expression of P450scc mRNA is detectable in the trunk kidney, while StAR mRNA is not quantifiable. 17alpha-ethynylestradiol produces time- and concentration-specific effects on the expression of the StAR, P450scc, P450arom isoforms and IGF-2 genes in gonadal tissues. In liver and kidney tissues exposed to the endocrine disrupting chemical 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, significant induction of both StAR and P450scc mRNA up

General Information

General Information Comment Organism
metabolism conversion of cholesterol to pregnenolone by P450scc represents the initiation of steroidogenesis Salmo salar
physiological function endocrine disrupting chemical modulation of acute steroid hormone regulation by targeting StAR and P450scc may have severe consequences for the entire reproduction process, including oocyte growth, development and overt fecundity Gadus morhua
physiological function expression of StAR and P450scc transcripts is related to steroid synthesis Oncorhynchus mykiss