Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment of adult rate ventricular myocytes ACTH and angiotensin II has no stimulatory effect on CYP11B1 and CYP11B2 expression | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxy-cortisol + reduced ferredoxin + O2 | Rattus norvegicus | - |
cortisol + ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced ferredoxin + O2 | Rattus norvegicus | - |
aldosterone + ferredoxin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats with heart failure induced by coronary artery ligation and sham-operated controls, stroke-prone spontaneously hypertensive rats and Wistar Kyoto rats as controls, cyp1a1Ren-2 transgenic rats and Fischer controls, and adult Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Rattus norvegicus | - |
heart | cardiac tissue from several rat models of cardiovascular pathology, low constitutive expression, which seems to be of no physiologic relevance | Rattus norvegicus | - |
additional information | no activity in adult ventricular myocyte | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
CYP11B2 and CYP11B1 expression analysis in male Wistar rats with heart failure induced by coronary artery ligation and sham-operated controls, in stroke-prone spontaneously hypertensive rats and Wistar Kyoto rats as controls, in cyp1a1Ren-2 transgenic rats and Fischer controls, and in isolated adult Sprague-Dawley ventricular myocytes incubated with 11-deoxycorticosterone, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxy-cortisol + reduced ferredoxin + O2 | - |
Rattus norvegicus | cortisol + ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced ferredoxin + O2 | - |
Rattus norvegicus | aldosterone + ferredoxin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxylase | - |
Rattus norvegicus |
Aldosterone synthase | - |
Rattus norvegicus |
CYP11B1 | - |
Rattus norvegicus |
CYP11B2 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Ferredoxin | - |
Rattus norvegicus |