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Literature summary for 1.14.15.34 extracted from

  • Reeves, C.D.; Ward, S.L.; Revill, W.P.; Suzuki, H.; Marcus, M.; Petrakovsky, O.V.; Marquez, S.; Fu, H.; Dong, S.D.; Katz, L.
    Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts (2004), Chem. Biol., 11, 1465-1472.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
20-oxo-5-O-beta-mycaminosyltylactone + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Streptomyces fradiae the enzyme is involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces 5-O-beta-mycaminosyltylonolide + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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Organism

Organism UniProt Comment Textmining
Streptomyces fradiae Q9ZHQ1
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
20-oxo-5-O-beta-mycaminosyltylactone + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
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Streptomyces fradiae 5-O-beta-mycaminosyltylonolide + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
?
20-oxo-5-O-beta-mycaminosyltylactone + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 the enzyme is involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces Streptomyces fradiae 5-O-beta-mycaminosyltylonolide + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
?

Synonyms

Synonyms Comment Organism
chmH
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Streptomyces fradiae
tylH1
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Streptomyces fradiae