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Literature summary for 1.14.15.31 extracted from

  • Hang, V.T.T.; Oh, T.J.; Yamaguchi, T.; Sohng, J.K.
    In vivo characterization of NcsB3 to establish the complete biosynthesis of the naphthoic acid moiety of the neocarzinostatin chromophore (2010), FEMS Microbiol. Lett., 311, 119-125.
    View publication on PubMed
Search for more literature for 1.14.15.31

Cloned(Commentary)

Cloned (Comment) Organism
heterologous expression of the gene together with ncsB and ncsB1 in Streptomyces lividans TK24 Streptomyces carzinostaticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Streptomyces carzinostaticus the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Streptomyces carzinostaticus ATCC 15944 the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces carzinostaticus Q84HB6
-
-
Streptomyces carzinostaticus ATCC 15944 Q84HB6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Streptomyces carzinostaticus 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin Streptomyces carzinostaticus 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Streptomyces carzinostaticus ATCC 15944 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin Streptomyces carzinostaticus ATCC 15944 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Synonyms

Synonyms Comment Organism
NcsB3
-
 Streptomyces carzinostaticus

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450 a heme-thiolate protein Streptomyces carzinostaticus