Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17-octadecynoic acid | irreversible CYP omega-hydroxylase inhibitor, significantly inhibits myocardial apoptosis | Rattus norvegicus | |
N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine | HET0016, a potent and selective inhibitor of CYP omega-hydroxylase, significantly inhibits myocardial apoptosis. Pretreatment with PD98059, the inhibitor of ERK1/2, but not SB203580 or SP600125, almost completely blocks the effect exerted by HET0016. Exogenous 20-hydroxyeicosatetraenoic acid administration exerts opposite effects | Rattus norvegicus | |
N-methylsulfonyl-12, 12-dibromododec-11-enamide | a selective CYP omega-hydroxylase inhibitor, significantly inhibits myocardial apoptosis | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
adult male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonic acid + NAD(P)H + H+ + O2 | - |
Rattus norvegicus | (5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP omega hydroxylase | - |
Rattus norvegicus |
cytochrome P450 omega hydroxylase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | CYP omega-hydroxylase inhibition exerts significant anti-apoptosis effects, at least in part, by activation of ERK1/2 in ischemia/reperfusion heart. Inhibition reduces the infarct size of heart, decreases DNA fragmentation, reduces TUNEL-positive cells, attenuates caspase-3 activation, and modulates genes associated with apoptosis in rats rendered ischemia followed by reperfusion | Rattus norvegicus |