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Literature summary for 1.14.15.18 extracted from

  • Diaz, L.; Arranz, C.; Avila, E.; Halhali, A.; Vilchis, F.; Larrea, F.
    Expression and activity of 25-hydroxyvitamin D-1alpha-hydroxylase are restricted in cultures of human syncytiotrophoblast cells from preeclamptic pregnancies (2002), J. Clin. Endocrinol. Metab., 87, 3876-3882.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Epidermal growth factor stimulates Homo sapiens
Epidermal growth factor i.e. EGF Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
25-hydroxycholecalciferol + NADPH + O2 Homo sapiens central role in calcium regulation calcitriol + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O cytochrome P-450 enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta syncytiotrophoblast cells from preeclamptic pregnancies Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxycholecalciferol + NADPH + O2 central role in calcium regulation Homo sapiens calcitriol + NADP+ + H2O
-
?
calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Homo sapiens calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?