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Literature summary for 1.14.15.18 extracted from
- Subcellular location and properties of rat renal 25-hydroxyvitamin D3-1 alpha-hydroxylase (1985), J. Biol. Chem., 260, 11488-11492.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| succinate | supports 1alpha-hydroxylation as electron donor | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antimycin A | inhibition occurs with succinate reaction support, no inhibition together with malate | Rattus norvegicus | |
| dinitrophenol | - |
Rattus norvegicus | |
| diphenyl-p-phenylenediamine | no inhibition | Rattus norvegicus | |
| Metyrapone | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| calcidiol + NADPH + O2 | highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol | Rattus norvegicus | calcitriol + NADP+ + H2O | calcitriol is identical with 1,25-dihydroxycholecalciferol | ? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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