Application | Comment | Organism |
---|---|---|
medicine | elevated tumor CYP24A1 expression is associated with a poor prognosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(4-hydroxybenzyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | - |
Homo sapiens | |
CTA018 | - |
Homo sapiens | |
CTA091 | - |
Homo sapiens | |
ketoconazole | - |
Homo sapiens | |
liarozole | - |
Homo sapiens | |
VID400 | i.e. (R)-N-(2-(1H-imidazol-1-yl)-2-phenylethyl)-4-chlorobiphenyl-4-carboxamide, exhibits strong and selective CYP24A1 inhibitory activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | Homo sapiens | - |
1alpha,24,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D3 + NADPH + H+ + O2 | Homo sapiens | - |
24,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | highest activity in kidney | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Homo sapiens | 1alpha,24,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D3 + NADPH + H+ + O2 | - |
Homo sapiens | 24,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP24A1 | - |
Homo sapiens |
vitamin D 24-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000015 | - |
pH and temperature not specified in the publication | Homo sapiens | VID400 |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme expression is upregulated in cancer cells | up |