Literature summary for 1.14.15.16 extracted from

Prosser, D.E.; Kaufmann, M.; OLeary, B.; Byford, V.; Jones, G.
Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone (2007), Proc. Natl. Acad. Sci. USA, 104, 12673-12678.

Search for more literature for 1.14.15.16

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in V79-CYP24 or OK (CCL-1840) cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A326G	the mutation converts human CYP24A1 from 25-hydroxyvitamin-D3 24-hydroxylase into 25-hydroxyvitamin-D3 23-hydroxylase, generating 1alpha,25-dihydroxyvitamin D3-26,23-lactone	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2	C24-hydroxylation, the preferred pathway of human CYP24A1	Homo sapiens	1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O	-	?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2	C23-hydroxylation	Homo sapiens	1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O	-	?
additional information	25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) is a bifunctional enzyme capable of the 24-hydroxylation of 1alpha,25-dihydroxyvitamin D3, leading to the excretory form, calcitroic acid (calcitetrol), and 23-hydroxylation, culminating in 1alpha,25-dihydroxyvitamin D3-26,23-lactone	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
25-hydroxyvitamin D3-24-hydroxylase	-	Homo sapiens
CYP24A1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)