Activating Compound | Comment | Organism | Structure |
---|---|---|---|
calcitriol | calcitriol increases its own degradation in renal failure by increasing the enzymatic activity of 24-hydroxylase | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Rattus norvegicus | 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D3 + NADPH + H+ + O2 | - |
Rattus norvegicus | 24R,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
calcitriol + NADPH + H+ + O2 | - |
Rattus norvegicus | calcitetrol + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
24-hydroxylase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | the enzymatic activity of intestinal 24-hydroxylase is significantly lower in renal failure rats compared to control sham operated rats | down |
Rattus norvegicus | replacement of calcitriol (3 ng per day) significantly increases 24-hydroxylase activity by 17% in rats with renal failure, although the activity remains 15% lower than the controls | up |