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Literature summary for 1.14.15.16 extracted from

  • Patel, S.R.; Ke, H.Q.; Hsu, C.H.
    Effect of vitamin D metabolites on calcitriol degradative enzymes in renal failure (1994), Kidney Int., 45, 509-514.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
calcitriol calcitriol increases its own degradation in renal failure by increasing the enzymatic activity of 24-hydroxylase Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
Rattus norvegicus 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
?
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
Rattus norvegicus 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
?
calcitriol + NADPH + H+ + O2
-
Rattus norvegicus calcitetrol + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
24-hydroxylase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the enzymatic activity of intestinal 24-hydroxylase is significantly lower in renal failure rats compared to control sham operated rats down
Rattus norvegicus replacement of calcitriol (3 ng per day) significantly increases 24-hydroxylase activity by 17% in rats with renal failure, although the activity remains 15% lower than the controls up