BRENDA - Enzyme Database show
show all sequences of 1.14.15.16

Effect of the X-linked Hyp mutation and vitamin D status on induction of renal 25-hydroxyvitamin D3-24-hydroxylase

Tenenhouse, H.S.; Jones, G.; Endocrinology 120, 609-616 (1987)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
1alpha,25-dihydroxyvitamin D3
renal 24-hydroxylase is significantly stimulated by 1alpha,25-dihydroxyvitamin D3 treatment in both normal and Hyp mice. In normal mice, 1alpha,25-dihydroxyvitamin D3 treatment is more effective than calcium in turning on 24-hydroxylase activity. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone. 24-hydroxylase is 3fold, and 8fold greater in Hyp mice relative to normal treated with 1alpha,25-dihydroxyvitamin D3, and calcium plus 1alpha,25-dihydroxyvitamin D3, respectively
Mus musculus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
24-hydroxylase activity is 20fold greater in Hyp mice relative to normal treated with calcium. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
714835
Mus musculus
secalciferol + NADP+ + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Mus musculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
1alpha,25-dihydroxyvitamin D3
renal 24-hydroxylase is significantly stimulated by 1alpha,25-dihydroxyvitamin D3 treatment in both normal and Hyp mice. In normal mice, 1alpha,25-dihydroxyvitamin D3 treatment is more effective than calcium in turning on 24-hydroxylase activity. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone. 24-hydroxylase is 3fold, and 8fold greater in Hyp mice relative to normal treated with 1alpha,25-dihydroxyvitamin D3, and calcium plus 1alpha,25-dihydroxyvitamin D3, respectively
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Mus musculus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
24-hydroxylase activity is 20fold greater in Hyp mice relative to normal treated with calcium. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
714835
Mus musculus
secalciferol + NADP+ + H2O
-
-
-
?
Other publictions for EC 1.14.15.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736557
Mugg
Quantitation of CYP24A1 enzyma ...
Homo sapiens
J. Clin. Endocrinol. Metab.
100
684-688
2015
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1
1
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736056
Ferla
Novel styryl-indoles as small ...
Homo sapiens
Eur. J. Med. Chem.
87
39-51
2014
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1
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736086
Tieu
Kinetic analysis of human CYP2 ...
Homo sapiens, Rattus norvegicus
FEBS J.
281
3280-3296
2014
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15
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15
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16
1
1
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1
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2
2
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736616
Ferla
Small-molecule inhibitors of 2 ...
Homo sapiens
J. Med. Chem.
57
7702-7715
2014
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1
1
-
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724907
Urbschat
Vitamin D hydroxylases CYP2R1, ...
Homo sapiens
Eur. J. Clin. Invest.
43
1282-1290
2013
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1
1
1
1
-
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728214
Luo
24-Hydroxylase in cancer: impa ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
136
252-257
2013
-
1
-
-
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-
6
-
1
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2
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1
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1
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1
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1
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2
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1
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1
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728215
Hoebaus
Epigenetic regulation of the 1 ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
136
296-299
2013
-
-
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5
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1
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1
-
-
736545
Rhieu
Metabolic stability of 3-epi-1 ...
Rattus norvegicus
J. Cell. Biochem.
114
2293-2305
2013
-
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-
-
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1
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11
-
1
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12
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11
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1
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12
-
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1
2
2
1
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-
736701
Hartfield
The novel purification and bio ...
Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
136
47-53
2013
-
-
1
-
2
-
10
-
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1
1
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1
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1
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3
1
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3
9
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1
3
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2
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10
9
-
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1
1
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1
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-
-
3
1
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-
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-
726809
Jones
25-Hydroxyvitamin D-24-hydroxy ...
Rattus norvegicus
Arch. Biochem. Biophys.
523
9-18
2012
-
-
-
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-
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2
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2
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1
1
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717838
Kaufmann
Bioengineering anabolic vitami ...
Homo sapiens
J. Biol. Chem.
286
28729-28737
2011
-
-
1
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3
-
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1
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1
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3
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714178
Zhu
Screening of selective inhibit ...
Homo sapiens
Biochemistry
49
10403-10411
2010
-
-
1
-
-
-
8
4
-
-
1
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-
4
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1
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4
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4
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2
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1
2
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8
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4
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1
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1
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4
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4
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4
4
716740
Prosser
Single A326G mutation converts ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
12673-12678
2007
-
-
1
-
1
-
-
-
-
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2
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3
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1
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1
1
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1
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3
-
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714302
Masuda
Evidence for the activation of ...
Homo sapiens, Mus musculus
Biochim. Biophys. Acta
1761
221-234
2006
-
-
-
-
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-
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5
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2
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2
2
-
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-
716274
Hamamoto
Structure-function analysis of ...
Homo sapiens, Rattus norvegicus
Mol. Pharmacol.
70
120-128
2006
-
-
1
-
10
-
-
9
-
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4
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5
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7
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1
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10
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9
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5
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7
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8
8
715091
Sakaki
Metabolism of vitamin D3 by cy ...
Homo sapiens, Rattus norvegicus
Front. Biosci.
10
119-134
2005
-
-
2
-
-
-
-
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6
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2
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3
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713944
Astecker
C-25 hydroxylation of 1alpha,2 ...
Homo sapiens, Rattus norvegicus
Arch. Biochem. Biophys.
431
261-270
2004
-
-
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4
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1
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6
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1
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3
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6
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714016
Kusudo
Metabolism of A-ring diastereo ...
Homo sapiens, Rattus norvegicus
Biochem. Biophys. Res. Commun.
321
774-782
2004
-
-
2
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5
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2
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10
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10
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714156
Sawada
Novel metabolism of 1 alpha,25 ...
Homo sapiens
Biochemistry
43
4530-4537
2004
-
-
1
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1
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716973
Prosser
Enzymes involved in the activa ...
Homo sapiens, Mus musculus
Trends Biochem. Sci.
29
664-673
2004
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2
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2
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2
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14
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2
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2
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2
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14
-
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2
3
3
2
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714836
Akeno
Mouse vitamin D-24-hydroxylase ...
Mus musculus
Endocrinology
138
2233-2240
1997
-
-
-
-
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-
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2
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5
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14
-
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2
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1
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1
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2
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14
-
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2
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-
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1
-
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1
-
-
714138
Beckman
Human 25-hydroxyvitamin D3-24- ...
Homo sapiens
Biochemistry
35
8465-8472
1996
2
-
1
-
-
-
-
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-
1
-
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3
-
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4
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1
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1
1
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1
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4
-
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1
1
-
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-
716071
Patel
Effect of vitamin D metabolite ...
Rattus norvegicus
Kidney Int.
45
509-514
1994
1
-
-
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2
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1
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3
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2
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2
-
-
714835
Tenenhouse
Effect of the X-linked Hyp mut ...
Mus musculus
Endocrinology
120
609-616
1987
1
-
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1
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2
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1
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1
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1
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715412
Danan
Presence of 25-hydroxyvitamin ...
Rattus norvegicus
J. Biol. Chem.
257
10715-10721
1982
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