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Literature summary for 1.14.15.1 extracted from

  • Zurek, J.; Foloppe, N.; Harvey, J.N.; Mulholland, A.J.
    Mechanisms of reaction in cytochrome P450: hydroxylation of camphor in P450cam (2006), Org. Biomol. Chem., 4, 3931-3937.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-camphor + O2 + reduced putidaredoxin Pseudomonas putida
-
(+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(+)-camphor + reduced putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O reaction mechanism involving a heme ring and residue Asp297, modelling of the hydroxylation of camphor and the hydrogen abstraction from heme using combined quantum mechanical/molecular mechanical method Pseudomonas putida

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-camphor + O2 + reduced putidaredoxin
-
Pseudomonas putida (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O
-
?
additional information modelling of the hydroxylation of camphor using crystal structure, PDB code 1DZ9, and combined quantum mechanical/molecular mechanical method, heme propionate side chains are not involved in catalysis, Asp297 is important for the reaction mechanism, overview Pseudomonas putida ?
-
?

Synonyms

Synonyms Comment Organism
cytochrome p450cam
-
Pseudomonas putida

Cofactor

Cofactor Comment Organism Structure
putidaredoxin
-
Pseudomonas putida