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Literature summary for 1.14.14.B11 extracted from

  • Wang, S.; Yang, S.; An, B.; Wang, S.; Yin, Y.; Lu, Y.; Xu, Y.; Hao, D.
    Molecular dynamics analysis reveals structural insights into mechanism of nicotine N-demethylation catalyzed by tobacco cytochrome P450 mono-oxygenase (2011), PLoS ONE, 6, e23342.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.B11

Protein Variants

Protein Variants Comment Organism
C330W inactive Nicotiana tabacum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2 Nicotiana tabacum
-
 nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Nicotiana tabacum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Nicotiana tabacum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2
-
 Nicotiana tabacum nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP82E4
-
 Nicotiana tabacum
NND
-
 Nicotiana tabacum

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Nicotiana tabacum
NADPH
-
 Nicotiana tabacum