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Literature summary for 1.14.14.94 extracted from
- Expression and physiological function of CYP4F subfamily in human eosinophils (2007), Biochim. Biophys. Acta, 1771, 1439-1445.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00064 | - |
leukotriene B4 | pH 7.5, 37°C | Homo sapiens |  |
| 0.0961 | - |
6-trans-leukotriene B4 | pH 7.5, 37°C | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | a cytochrome P450 enzyme | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | CYP4F3A is expressed in human leukocytes and catalyzes the omega-hydroxylation of LTB4 | (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eosinophil | - |
Homo sapiens | - |
| granulocyte | - |
Homo sapiens | - |
| leukocyte | - |
Homo sapiens | - |
| monocyte | - |
Homo sapiens | - |
| additional information | CYP4F3A expression analysis, overview | Homo sapiens | - |
| neutrophil | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 12-hydroxyeicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | CYP4F3A | Homo sapiens | ? | - |
? | |
| 6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | CYP4F3A | Homo sapiens | ? | - |
? | |
| leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | CYP4F3A is expressed in human leukocytes and catalyzes the omega-hydroxylation of LTB4 | Homo sapiens | (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | CYP4F3A catalyzes the omega-hydroxylation of LTB4 | Homo sapiens | (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2 | CYP4F3A | Homo sapiens | ? | - |
? | |
| additional information | CYP4F3A also catalyzes the omega-hydroxylation of epoxyeicosatrieonic acids | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP4F3 | - |
Homo sapiens |
| CYP4F3A | - |
Homo sapiens |
| LTB4 omega-hydroxylase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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