Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CO | - |
Rattus norvegicus | |
leukotriene B4 | substrate prostaglandin A1 | Rattus norvegicus | |
prostaglandin A1 | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
prostaglandin A1 | - |
Rattus norvegicus | |
0.042 | - |
leukotriene B4 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | inactivation of leukotriene B4, a mediator of inflammation | (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 | inactivation of leukotriene B4, a mediator of inflammation | Rattus norvegicus | (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | leukotriene B4 is identical with (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate | Rattus norvegicus | 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 20-hydroxy-prostaglandin A1 + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | enzyme contains cytochrome P-450 | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.038 | - |
prostaglandin A1 | - |
Rattus norvegicus | |
0.043 | - |
leukotriene B4 | substrate prostaglandin A1 | Rattus norvegicus |