Literature summary for 1.14.14.92 extracted from

Korosec, B.; Sova, M.; Turk, S.; Krasevec, N.; Novak, M.; Lah, L.; Stojan, J.; Podobnik, B.; Berne, S.; Zupanec, N.; Bunc, M.; Gobec, S.; Komel, R.
Antifungal activity of cinnamic acid derivatives involves inhibition of benzoate 4-hydroxylase (CYP53) (2014), J. Appl. Microbiol., 116, 955-966 .

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Application

Application	Comment	Organism
medicine	the enzyme is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to fungi, it is a promising drug target in fungal pathogens of other eukaryotes	Curvularia lunata
pharmacology	the enzyme is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to fungi, it is a promising drug target in fungal pathogens of other eukaryotes. By identifying selected derivatives of cinnamic acid as possible antifungal drugs, and CYP53 family enzymes as their targets, a potential inhibitor-target system for antifungal drugs is developed	Curvularia lunata

Cloned(Commentary)

Cloned (Comment)	Organism
His-tagged benzoate 4-monooxygenase is expressed in Escherichia coli C43(DE3) cells	Curvularia lunata

Inhibitors

Inhibitors	Comment	Organism	Structure
(E)-1-(4-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one	competitive inhibitor	Curvularia lunata

Organism

Organism	UniProt	Comment	Textmining
Curvularia lunata	B8QM33	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Curvularia lunata

Synonyms

Synonyms	Comment	Organism
CYP53A15	-	Curvularia lunata

General Information

General Information	Comment	Organism
drug target	the enzyme is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to fungi, it is a promising drug target in fungal pathogens of other eukaryotes	Curvularia lunata
metabolism	the enzyme is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi	Curvularia lunata

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Release 2023.1 (January 2023)