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Literature summary for 1.14.14.91 extracted from

  • Kong, J.Q.; Lu, D.; Wang, Z.B.
    Molecular cloning and yeast expression of cinnamate 4-hydroxylase from Ornithogalum saundersiae baker (2014), Molecules, 19, 1608-1621 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.91

Application

Application Comment Organism
pharmacology trans-cinnamate 4-monooxygenase plays a key role in the ability of phenylpropanoid metabolism to channel carbon to produce the 4-methoxybenzoyl group on the disaccharide moiety of OSW-1 (3beta,16beta,17alpha-trihydroxycholest-5-en-22-one 16-O-[O-[2-O-(4-methoxybenzoyl)-beta-D-xylopyranosyl]-(1->3)-2-O-acetyl-alpha-L-arabinopyranoside]). OSW-1 is about 10-100 times more cytotoxic than clinically applied anticanceragents such as mitomycin C, adriamycin, cisplatin, camptothecin, and paclitaxel, but has a low toxicity towards normal cells. This potency, in combination with a unique mechanism of action and selectivity toward malignant tumor cells, gives OSW-1 and its analogues great potential as anticancer agents Ornithogalum saundersiae

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Ornithogalum saundersiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57800
-
 calculated from sequence Ornithogalum saundersiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2 Ornithogalum saundersiae
-
 4-hydroxycinnamate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Ornithogalum saundersiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2
-
 Ornithogalum saundersiae 4-hydroxycinnamate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
OsaC4H
-
 Ornithogalum saundersiae

pI Value

Organism Comment pI Value Maximum pI Value
Ornithogalum saundersiae calculated from sequence
-
 9.22

General Information

General Information Comment Organism
metabolism the enzyme plays a key role in the ability of phenylpropanoid metabolism to channel carbon to produce the 4-methoxybenzoyl group on the disaccharide moiety of OSW-1 (3beta,16beta,17alpha-trihydroxycholest-5-en-22-one 16-O-[O-[2-O-(4-methoxybenzoyl)-beta-D-xylopyranosyl]-(1->3)-2-O-acetyl-alpha-L-arabinopyranoside]). OSW-1 is about 10-100 times more cytotoxic than clinically applied anticanceragents such as mitomycin C, adriamycin, cisplatin, camptothecin, and paclitaxel, but has a low toxicity towards normal cells. This potency, in combination with a unique mechanism of action and selectivity toward malignant tumor cells, gives OSW-1 and its analogues great potential as anticancer agents Ornithogalum saundersiae