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Literature summary for 1.14.14.91 extracted from

  • Park, J.H.; Park, N.I.; Xu, H.; Park, S.U.
    Cloning and characterization of phenylalanine ammonia-lyase and cinnamate 4-hydroxylase and pyranocoumarin biosynthesis in Angelica gigas (2010), J. Nat. Prod., 73, 1394-1397.
    View publication on PubMed
Search for more literature for 1.14.14.91

Cloned(Commentary)

Cloned (Comment) Organism
gene C4H, DNA and amino acid sequence determination and analysis, expression analysis by quantitative real-time PCR after elicitor treatment Angelica gigas

Protein Variants

Protein Variants Comment Organism
up the enzyme is induced by pathogens, quantitative real-time PCR expression analysis after elicitor treatment, overview Angelica gigas

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2 Angelica gigas
-
 4-coumaric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2 Angelica gigas Nakai
-
 4-coumaric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Angelica gigas F4YRL2
-
-
Angelica gigas Nakai F4YRL2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell suspension culture
-
 Angelica gigas
-
fine root highest expression level Angelica gigas
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2
-
 Angelica gigas 4-coumaric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2
-
 Angelica gigas Nakai 4-coumaric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
C4H
-
 Angelica gigas
cinnamate 4-hydroxylase
-
 Angelica gigas
More C4H is a member of the CYP73 family of cytochrome P450 monooxygenases Angelica gigas

Expression

Organism Comment Expression
Angelica gigas methyl jasmonate induces the enzyme highest at 0.3 mM after 12 h treatment up

General Information

General Information Comment Organism
metabolism cinnamate 4-hydroxylase is an important enzyme in the phenylpropanoid pathway and also in the accumulation of decursin and decursinol angelate, which are major secondary metabolites in Angelica gigas Angelica gigas
physiological function C4H controls the carbon flux for many phytoalexins that are synthesized when plants are challenged by pathogens Angelica gigas