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Literature summary for 1.14.14.83 extracted from
- Overexpression of geraniol 10-hydroxylase from Panax ginseng conferred enhanced resistance to Pseudomonas syringae in Arabidopsis (2017), Plant Growth Regul., 81, 305-316 .
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene G10H, DNA and amino acid sequence determination and analysis, phylogenetic analysis and tree, quantitative RT-PCR enzyme expression analysis. Recombinant overexpression of the ginseng geraniol 10-hydroxylase P450 gene in Arabidopsis thaliana ecotype CS60000, from vector pCAMBIA1390 under control of promoter CaMV 35S, causes terpenoid indole alkaloid dihydrositsirikine production and also confers enhanced resistance to Pseudomonas syringae pv. tomato DC3000 | Panax ginseng |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | G10H is a transmembrane protein containing a transmembrane helix at the N-terminus | Panax ginseng | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geraniol + [reduced NADPH-hemoprotein reductase] + O2 | Panax ginseng | - |
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Panax ginseng | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| flower | moderate enzyme expression level | Panax ginseng | - |
| leaf | low enzyme expression level | Panax ginseng | - |
| additional information | tissue-specific expression pattern and expression of PgG10H in response to various biotic and abiotic stresses | Panax ginseng | - |
| root | high enzyme expression level | Panax ginseng | - |
| stem | moderate enzyme expression level | Panax ginseng | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geraniol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Panax ginseng | 10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | secondary structure and three-dimensional structure analysis, overview | Panax ginseng |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G10H | - |
Panax ginseng |
| geraniol 10-hydroxylase | - |
Panax ginseng |
| PgCYP76C9 | - |
Panax ginseng |
| PgG10H | - |
Panax ginseng |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | a cytochrome P450 monooxygenase | Panax ginseng | |
| NADPH | - |
Panax ginseng | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Panax ginseng | tissue-specific expression pattern and expression of PgG10H in response to various biotic and abiotic stresses | additional information |
| Panax ginseng | the expression of PgG10H is differentially induced in ginseng, not only during Pseudomonas syringae infection and wounding but also after exposure to methyl jasmonate and salt stress | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is involved in the secoiridoid pathway and the biosynthesis of terpenoid indole alkaloid via strictosidine | Panax ginseng |
| additional information | molecular docking is used for accurate prediction of protein-ligand interaction geometries at molecular level, molecular interaction studies, overview. Geraniol interacts with G10H residues Ala303 and Thr307 from the central helix I | Panax ginseng |
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Release 2023.1 (January 2023)
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