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Literature summary for 1.14.14.83 extracted from

  • Peebles, C.A.; Sander, G.W.; Hughes, E.H.; Peacock, R.; Shanks, J.V.; San, K.Y.
    The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots (2010), Metab. Eng., 13, 234-240.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Catharanthus roseus hairy roots via Agrobacterium rhizogenes 15834 transfection system, co-expression with the 1-deoxy-D-xylulose synthase, DXS, from Arabidopsis thaliana Catharanthus roseus

Protein Variants

Protein Variants Comment Organism
additional information co-overexpression of G10H with the 1-deoxy-D-xylulose synthase, DXS, from Arabidopsis thaliana causes a significant increase in ajmalicine by 16%, lochnericine by 31% and tabersonine by 13%. To increase the flux toward vinblastine and vincristine, a multiple genes within the pathway need to be overexpressed, terpenoid indole alkaloid profile, overview Catharanthus roseus
additional information construction of hairy root lines with inducible overexpression of 1-deoxy-D-xylulose synthase, DXS, or geraniol-10-hydroxylase, G10H Catharanthus roseus

Organism

Organism UniProt Comment Textmining
Catharanthus roseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hairy root
-
Catharanthus roseus
-

Synonyms

Synonyms Comment Organism
G10H
-
Catharanthus roseus
geraniol-10-hydroxylase
-
Catharanthus roseus

General Information

General Information Comment Organism
metabolism the enzyme is part of the terpenoid indole alkaloid pathway Catharanthus roseus
additional information the individual overexpression of the terpenoid genes 1-deoxy-D-xylulose synthase, DXS, and G10H resulted in mixed results in regards to the accumulation of terpenoid indole alkaloid metabolite pools Catharanthus roseus