Literature summary for 1.14.14.80 extracted from

Saito, T.; Honda, M.; Takahashi, M.; Tsukada, C.; Ito, M.; Katono, Y.; Hosono, H.; Saigusa, D.; Suzuki, N.; Tomioka, Y.; Hirasawa, N.; Hiratsuka, M.
Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid omega-hydroxylation (2015), Drug Metab. Pharmacokinet., 30, 119-122 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS-7 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
F434S	allelic variant, 36% decrease in vamx	Homo sapiens
G130S	allelic variant, almost inactive	Homo sapiens
K276T	allelic variant	Homo sapiens
L509S	allelic variant, 2.2fold increase in Km	Homo sapiens
P428L	allelic variant, almost inactive	Homo sapiens
S353G	allelic variant	Homo sapiens
V185F	allelic variant, 4fold increase in Km, 88% decrease in vamx	Homo sapiens
W126R	allelic variant, almost inactive	Homo sapiens
Y152N	allelic variant, 95% decrease in vmax	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0449	-	arachidonic acid	mutant K276T, pH 7.4, 37°C	Homo sapiens
0.051	-	arachidonic acid	mutant F434S, pH 7.4, 37°C	Homo sapiens
0.0552	-	arachidonic acid	mutant S353G, pH 7.4, 37°C	Homo sapiens
0.0564	-	arachidonic acid	wild-type, pH 7.4, 37°C	Homo sapiens
0.0983	-	arachidonic acid	mutant Y152N, pH 7.4, 37°C	Homo sapiens
0.122	-	arachidonic acid	mutant L509S, pH 7.4, 37°C	Homo sapiens
0.25	-	arachidonic acid	mutant V185F, pH 7.4, 37°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q02928	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	20-hydroxy arachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

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Release 2023.1 (January 2023)