Cloned (Comment) | Organism |
---|---|
expressed from pFastbacCYP4V2HIS vector in Escherichia coli DH10Bac. Hexahistidine-tagged CYP4V2 is expressed in Sf-9 cells after infection with the recombinant baculovirus | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-N'-(4-butyl-2-methylphenyl)-N-hydroxyformimidamide | HET0016 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.065 | - |
myristic acid | - |
Homo sapiens | |
0.14 | - |
lauric acid | - |
Homo sapiens | |
0.43 | - |
palmitic acid | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
by Coomassie staining and by immunoblotting | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lauric acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | octanoic acid is not detectably omega-hydroxylated by CYP4V2 | Homo sapiens | ? | - |
? | |
myristic acid + [reduced NADPH-hemoprotein reductase] + O2 | CYP4V2 is a selective omega-hydroxylase of saturated, medium-chain fatty acids with relatively high catalytic efficiency toward myristic acid | Homo sapiens | 12-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP4V2 | - |
Homo sapiens |
Fatty acid omega-hydroxylase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000038 | - |
- |
Homo sapiens | (E)-N'-(4-butyl-2-methylphenyl)-N-hydroxyformimidamide |
General Information | Comment | Organism |
---|---|---|
physiological function | defective omega-oxidation of ocular fatty acids/lipids secondary to mutations in the CYP4V2 gene may be a plausible mechanism underlying Bietti's crystalline dystrophy | Homo sapiens |