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Literature summary for 1.14.14.74 extracted from

  • Wu, Z.; Lee, D.; Joo, J.; Shin, J.; Kang, W.; Oh, S.; Lee, D.; Lee, S.; Yea, S.; Lee, H.; Lee, T.; Liu, K.
    CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems (2013), Antimicrob. Agents Chemother., 57, 5448-5456 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
albendazole + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P51589
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP2J2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function albendazole hydroxylation correlates with CYP2J2 activity Homo sapiens