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Literature summary for 1.14.14.73 extracted from

  • Lee, C.; Neul, D.; Clouser-Roche, A.; Dalvie, D.; Wester, M.; Jiang, Y.; Jones III, J.; Freiwald, S.; Zientek, M.; Totah, R.
    Identification of novel substrates for human cytochrome P450 2J2 (2010), Drug Metab. Dispos., 38, 347-356 .
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol with in vitro intrinsic clearance values ranging from 0.06 to 3.98 microl/min/pmol CYP2J2. Whereas isoform CYP3A4 commonly metabolizes compounds at multiple sites, CYP2J2 metabolism is more restrictive and limited, in general, to a single site for large compounds Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
homology modeling of structure Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P51589
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
amiodarone + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
astemizole + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
cyclosporin + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
danazol + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
mesoridazine + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
additional information enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol. The substrates vary in size and overall topology from relatively rigid structures (amiodarone) to larger complex structures (cyclosporine). CYP2J2 metabolism is more restrictive than that of YP3A4 and limited, in general, to a single site for large compounds Homo sapiens ?
-
?
thioridazine + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
cytochrome P450 2J2
-
Homo sapiens