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Literature summary for 1.14.14.61 extracted from

  • Scheler, U.; Brandt, W.; Porzel, A.; Rothe, K.; Manzano, D.; Bozic, D.; Papaefthimiou, D.; Balcke, G.; Henning, A.; Lohse, S.; Marillonnet, S.; Kanellis, A.; Ferrer, A.; Tissier, A.
    Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast (2016), Nat. Commun., 7, 12942 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Nicotiana benthamiana leaf Salvia rosmarinus
expression in Nicotiana benthamiana leaf Salvia fruticosa

Organism

Organism UniProt Comment Textmining
Salvia fruticosa
-
-
-
Salvia pomifera A0A0S1TPC7
-
-
Salvia rosmarinus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
trichome glandular trichome Salvia rosmarinus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-hydroxyferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
-
Salvia rosmarinus carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
?
11-hydroxyferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
-
Salvia pomifera carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
?
11-hydroxyferruginol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2
-
Salvia fruticosa carnosic acid + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
?
additional information reaction intermediates are 11,20-dohydroxyferruginol and carnosaldehyde, which itself spontaneously oxidizes to carnosol. The enzyme can also oxidize miltiradiene and ferruginol, the latter leading to pisifieric acid, albeit with much lower efficiency, indicating 11-hydroxyferruginol is their preferred substrate Salvia rosmarinus ?
-
?
additional information reaction intermediates are 11,20-dohydroxyferruginol and carnosaldehyde, which itself spontaneously oxidizes to carnosol. The enzyme can also oxidize miltiradiene and ferruginol, the latter leading to pisifieric acid, albeit with much lower efficiency, indicating 11-hydroxyferruginol is their preferred substrate Salvia pomifera ?
-
?
additional information reaction intermediates are 11,20-dohydroxyferruginol and carnosaldehyde, which itself spontaneously oxidizes to carnosol. The enzyme can also oxidize miltiradiene and ferruginol, thelatter leading to pisifieric acid, albeit with much lower efficiency, indicating 11-hydroxyferruginol is their preferred substrate Salvia fruticosa ?
-
?

Synonyms

Synonyms Comment Organism
CYP76AK6
-
Salvia pomifera
CYP76AK7
-
Salvia fruticosa
CYP76AK8
-
Salvia rosmarinus
CYP76AK8
-
Salvia fruticosa