Literature summary for 1.14.14.60 extracted from

Guo, J.; Ma, X.; Cai, Y.; Ma, Y.; Zhan, Z.; Zhou, Y.J.; Liu, W.; Guan, M.; Yang, J.; Cui, G.; Kang, L.; Yang, L.; Shen, Y.; Tang, J.; Lin, H.; Ma, X.; Jin, B.; Liu, Z.; Peters, R.J.; Zhao, Z.K.; Huang, L.
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones (2016), New Phytol., 210, 525-534 .

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Organism

Organism	UniProt	Comment	Textmining
Salvia miltiorrhiza	A0A0Y0GRS3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
root	expression is more abundant in the root than in aerial tissues	Salvia miltiorrhiza	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ferruginol + [reduced NADPH-hemoprotein reductase] + O2	-	Salvia miltiorrhiza	11-hydroxyferruginol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
additional information	enzyme additionally oxidizes at C-7 to yield sugiol, reaction of EC 1.14.14.65	Salvia miltiorrhiza	?	-	?
sugiol + [reduced NADPH-hemoprotein reductase] + O2	-	Salvia miltiorrhiza	11-hydroxysugiol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP76AH3	-	Salvia miltiorrhiza

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome P450	-	Salvia miltiorrhiza

General Information

General Information	Comment	Organism
physiological function	cytochrome CYP76AH3 oxidizes ferruginol at two different carbon centers, and CYP76AK1 hydroxylates at C-20 of two of the resulting intermediates. Together, they convert ferruginol into 11,20-dihydroxy ferruginol and 11,20-dihydroxy sugiol en route to tanshinones. Silencing of CYP76AH3 leads to significant reduction in concentration of 11-hydroxyferruginol and 11-hydroxysugiol	Salvia miltiorrhiza

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Release 2023.1 (January 2023)