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Literature summary for 1.14.14.55 extracted from
- Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes (1997), Br. J. Clin. Pharmacol., 44, 505-511 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not activated by 0.025 mM 2-naphthoflavone | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cimetidine | - |
Homo sapiens |  |
| diltiazem | - |
Homo sapiens | |
| doxycycline | - |
Homo sapiens | |
| erythromycin | - |
Homo sapiens | |
| hydralazine | - |
Homo sapiens | |
| ketoconazole | - |
Homo sapiens | |
| additional information | not inhibited by lignocaine, pyrimethamine, dapsone, chloroquine, diazepam, norfloxacin, proguanil, cycloguanil, and 4-chlorophenylbiguanide | Homo sapiens | |
| nifepidine | - |
Homo sapiens | |
| oleandomycin | - |
Homo sapiens | |
| Omeprazole | - |
Homo sapiens | |
| primaquine | - |
Homo sapiens | |
| tetracycline | - |
Homo sapiens | |
| troleandomycin | - |
Homo sapiens | |
| verapamil | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| quinine + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| quinine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| tacrolimus + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP3A4 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000026 | - |
at pH 7.4 and 37°C | Homo sapiens | ketoconazole | |
| 0.0083 | - |
at pH 7.4 and 37°C | Homo sapiens | troleandomycin | |
| 0.017 | - |
at pH 7.4 and 37°C | Homo sapiens | doxycycline | |
| 0.018 | - |
at pH 7.4 and 37°C | Homo sapiens | Omeprazole | |
| 0.02 | - |
at pH 7.4 and 37°C | Homo sapiens | primaquine | |
| 0.029 | - |
at pH 7.4 and 37°C | Homo sapiens | tetracycline | |
| 0.038 | - |
at pH 7.4 and 37°C | Homo sapiens | nifepidine | |
| 0.061 | - |
at pH 7.4 and 37°C | Homo sapiens | erythromycin | |
| 0.064 | - |
at pH 7.4 and 37°C | Homo sapiens | verapamil | |
| 0.097 | - |
at pH 7.4 and 37°C | Homo sapiens | cimetidine | |
| 0.127 | - |
at pH 7.4 and 37°C | Homo sapiens | diltiazem | |
| 0.143 | - |
at pH 7.4 and 37°C | Homo sapiens | oleandomycin | |
| 0.197 | - |
at pH 7.4 and 37°C | Homo sapiens | hydralazine | |
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