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Literature summary for 1.14.14.54 extracted from

  • Rodriguez-Saiz, M.; Barredo, J.L.; Moreno, M.A.; Fernandez-Canon, J.M.; Penalva, M.A.; Diez, B.
    Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains (2001), J. Bacteriol., 183, 5465-5471 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
L181F the mutation is responsible for the reduced function of the enzyme Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2 Penicillium chrysogenum
-
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2 Penicillium chrysogenum NRRL 1951
-
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Penicillium chrysogenum Q9URR6
-
-
Penicillium chrysogenum NRRL 1951 Q9URR6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
-
Penicillium chrysogenum (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
phenylacetate + [reduced NADPH-hemoprotein reductase] + O2
-
Penicillium chrysogenum NRRL 1951 (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
PA 2-hydroxylase
-
Penicillium chrysogenum
phaA
-
Penicillium chrysogenum
phenylacetate, NAD(P):oxygen oxidoreductase (2-hydroxylating)
-
Penicillium chrysogenum