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Literature summary for 1.14.14.37 extracted from

  • Busk, P.K.; Moller, B.L.
    Dhurrin synthesis in sorghum is regulated at the transcriptional level and induced by nitrogen fertilization in older plants (2002), Plant Physiol., 129, 1222-1231.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
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Sorghum bicolor
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH-hemoprotein reductase] + O2 Sorghum bicolor involved in dhurrin synthesis (S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Sorghum bicolor
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L. Moench
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Sorghum bicolor O48958
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-

Source Tissue

Source Tissue Comment Organism Textmining
leaf the site of dhurrin synthesis shifts from leaves to stem during plant development. At all stages, the content of dhurrin correlates well with the activity of the two biosynthetic enzymes, CYP79A1 and CYP71E1, and with the protein and mRNA level for the two enzymes Sorghum bicolor
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seed maximal activity after 1 day of germination Sorghum bicolor
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stem the site of dhurrin synthesis shifts from leaves to stem during plant development. At all stages, the content of dhurrin correlates well with the activity of the two biosynthetic enzymes, CYP79A1 and CYP71E1, and with the protein and mRNA level for the two enzymes Sorghum bicolor
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH-hemoprotein reductase] + O2
-
Sorghum bicolor (S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
?
(E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH-hemoprotein reductase] + O2 involved in dhurrin synthesis Sorghum bicolor (S)-4-hydroxymandelonitrile + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
?

Synonyms

Synonyms Comment Organism
CYP71E1
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Sorghum bicolor

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Sorghum bicolor

General Information

General Information Comment Organism
physiological function at all stages, the content of dhurrin correlates well with the activity of the two biosynthetic enzymes, CYP79A1 and CYP71E1, and with the protein and mRNA level for the two enzymes. During development, the activity of tyrosine N-monooxygenase CYP79A1 is lower than the activity of 4-hydroxyphenylacetaldehyde oxime monooxygenase CYP71E1, suggesting that CYP79A1 catalyzes the rate-limiting step in dhurrin synthesis Sorghum bicolor