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Literature summary for 1.14.14.36 extracted from

  • Clausen, M.; Kannangara, R.M.; Olsen, C.E.; Blomstedt, C.K.; Gleadow, R.M.; Jorgensen, K.; Bak, S.; Motawie, M.S.; Moller, B.L.
    The bifurcation of the cyanogenic glucoside and glucosinolate biosynthetic pathways (2015), Plant J., 84, 558-573.
    View publication on PubMed
Search for more literature for 1.14.14.36

Cloned(Commentary)

Cloned (Comment) Organism
expression in Nicotiana tabacum Sorghum bicolor

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Sorghum bicolor 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase] Sorghum bicolor
-
 (E)-[4-hydroxyphenylacetaldehyde oxime] + 2 [oxidized NADPH-hemoprotein reductase] + CO2 + 3 H2O overall reaction ?
L-tyrosine + O2 + [reduced NADPH-hemoprotein reductase] Sorghum bicolor
-
 N-hydroxy-L-tyrosine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
N,N-dihydroxy-L-tyrosine Sorghum bicolor
-
 (E)-[4-hydroxyphenylacetaldehyde oxime] + CO2 + H2O
-
 ?
N-hydroxy-L-tyrosine + O2 + [reduced NADPH-hemoprotein reductase] Sorghum bicolor
-
 N,N-dihydroxy-L-tyrosine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Sorghum bicolor Q43135
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase]
-
 Sorghum bicolor (E)-[4-hydroxyphenylacetaldehyde oxime] + 2 [oxidized NADPH-hemoprotein reductase] + CO2 + 3 H2O overall reaction ?
L-tyrosine + O2 + [reduced NADPH-hemoprotein reductase]
-
 Sorghum bicolor N-hydroxy-L-tyrosine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
N,N-dihydroxy-L-tyrosine
-
 Sorghum bicolor (E)-[4-hydroxyphenylacetaldehyde oxime] + CO2 + H2O
-
 ?
N-hydroxy-L-tyrosine + O2 + [reduced NADPH-hemoprotein reductase]
-
 Sorghum bicolor N,N-dihydroxy-L-tyrosine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

General Information

General Information Comment Organism
physiological function the biosynthetic pathway for the cyanogenic glucoside dhurrin in Sorghum involves the sequential production of (E)- and (Z)-4-hydroxyphenylacetaldoxime. Monooxygenae CYP79A1 catalyzes conversion of tyrosine to (E)-4-hydroxyphenylacetaldoxime, whereas monooxygenase CYP71E1 catalyzes conversion of (E)-4-hydroxyphenylacetaldoxime into the corresponding geometrical Z-isomer as required for its dehydration into a nitrile, the next intermediate in cyanogenic glucoside synthesis Sorghum bicolor