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Literature summary for 1.14.14.32 extracted from

  • Yoshimoto, F.K.; Auchus, R.J.
    The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1) (2015), J. Steroid Biochem. Mol. Biol., 151, 52-65.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
androsterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
17alpha-hydroxy-5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
5alpha-androstanedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
17alpha-hydroxy-5alpha-dihydroprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05093
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
brain
-
Homo sapiens
-
gonad
-
Homo sapiens
-
heart
-
Homo sapiens
-
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens androsterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
17alpha-hydroxy-5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 5alpha-androstanedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 17alpha-hydroxy-5alpha-dihydroprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
additional information the enzyme shows also about 20% 16alpha-hydroxylase activity and some 21alpha-hydroxylase activity with progesterone Homo sapiens ?
-
?
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
17alpha-hydroxylase
-
Homo sapiens
CYP17A1
-
Homo sapiens
cytochrome P450 17A1
-
Homo sapiens
P450c17
-
Homo sapiens