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Literature summary for 1.14.14.32 extracted from

  • Li, Y.; Liang, X.; Wei, L.; Xiong, Y.; Yang, X.; Shi, H.; Yang, Z.
    Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo (2009), Reprod. Biol. Endocrinol., 7, 73-80.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development silencing CYP17 expression may be a strategy for therapy of hyperandrogenism diseases, and also sets an example for the use of RNAi technology in endocrine diseases Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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female Sprague-Dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
ovarian theca-interstitial cell
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Rattus norvegicus
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Synonyms

Synonyms Comment Organism
17alpha-hydroxylase/17,20-lyase
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Rattus norvegicus
CYP17
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Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus shRNA treatment significantly decreases CYP17 mRNA and protein levels in vitro. Silence efficiency of three constructed lentivirus shRNAs is 65.5%, 73.7% and 77.4%, respectively. Three constructed lentivirus shRNAs also have silencing effects on CYP17 protein expression, and their silence efficiencies are 50%, 50% and 61%, respectively. In vivo, shRNA still has a specific silencing effect on CYP17 down

General Information

General Information Comment Organism
malfunction ovarian androgen biosynthesis can be inhibited by silencing CYP17 expression Rattus norvegicus