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Literature summary for 1.14.14.32 extracted from
- Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis (1997), DNA Cell Biol., 16, 357-368.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| full length cDNA clone encoding cytochrome P450C17 expressed in COS 1 cells | Mesocricetus auratus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mesocricetus auratus | adrenal cytochrome P450C17 enzyme is capable of transforming pregnenolone into DHEA | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mesocricetus auratus | - |
Golden Syrian hamster | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17alpha-Hydroxypregnenolone | - |
Mesocricetus auratus | Dehydroepiandrosterone + acetaldehyde | DHEA | ? | |
| 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mesocricetus auratus | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | androstenedione | ? | |
| additional information | adrenal cytochrome P450C17 enzyme is capable of transforming pregnenolone into DHEA | Mesocricetus auratus | ? | - |
? | |
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