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Literature summary for 1.14.14.29 extracted from
- Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA (1997), J. Biol. Chem., 272, 23995-24001.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | Mus musculus | dietary cholesterol or colestipol do not affect oxysterol 7alpha-hydroxylase enzyme activity, mRNA, or protein levels | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | enzyme is induced in the third week of life | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | - |
Mus musculus | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
| cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | dietary cholesterol or colestipol do not affect oxysterol 7alpha-hydroxylase enzyme activity, mRNA, or protein levels | Mus musculus | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP7B1 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P-450 | - |
Mus musculus | |
| NADPH | - |
Mus musculus | |
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