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Literature summary for 1.14.14.29 extracted from
- CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids (2009), Biochim. Biophys. Acta, 1791, 1206-1215.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| from pCMV6 vector overexpressed in HEK-293 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5alpha-androstane-3alpha,17beta-diol | inhibition of the reaction with dehydroepiandrosterone | Homo sapiens |  |
| 5alpha-androstane-3alpha,17beta-diol | inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation | Sus scrofa | |
| additional information | testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities | Sus scrofa |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Sus scrofa | - |
- |
| microsome | - |
Mus musculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | O75881 | - |
- |
| Mus musculus | Q60991 | - |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Mus musculus | - |
| SH-SY5Y cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Homo sapiens | 5alpha-androstane-3alpha,7alpha,17beta-triol + NADP+ + H2O | major product, plus some hydroxylation at position 6 | ? | |
| 5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Sus scrofa | 5alpha-androstane-3alpha,7alpha,17beta-triol + NADP+ + H2O | major product, plus some hydroxylation at position 6 | ? | |
| 5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Sus scrofa | ? + NADP+ + H2O | - |
? | |
| 5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Homo sapiens | ? + NADP+ + H2O | - |
? | |
| 5alpha-androstane-3alpha,17beta-diol + NADPH + O2 | - |
Mus musculus | ? + NADP+ + H2O | - |
? | |
| dehydroepiandrosterone + NADPH + H+ + o2 | - |
Mus musculus | 7alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O | - |
? | |
| dehydroepiandrosterone + NADPH + H+ + O2 | - |
Homo sapiens | ? + NADP+ + H2O | - |
? | |
| dehydroepiandrosterone + NADPH + H+ + O2 | - |
Sus scrofa | ? + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP7B1 | - |
Homo sapiens |
| CYP7B1 | - |
Sus scrofa |
| CYP7B1 | - |
Mus musculus |
| Steroid hydroxylase | - |
Sus scrofa |
| Steroid hydroxylase | - |
Homo sapiens |
| Steroid hydroxylase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Sus scrofa | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | activity towards 5alpha-androstane-3alpha,17beta-diol is very low or undetectable in livers of Cyp7b1(-/-) knockout mice. CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens | Mus musculus |
| physiological function | CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens | Sus scrofa |
| physiological function | CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens | Homo sapiens |
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