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Literature summary for 1.14.14.29 extracted from

  • Li-Hawkins, J.; Lund, E.G.; Bronson, A.D.; Russell, D.W.
    Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol (2000), J. Biol. Chem., 275, 16543-16549.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver higher activity in male than in female Mus musculus
-
liver higher activity in male than in female Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
22-hydroxycholesterol + NADPH + H+ + O2
-
Mus musculus 7alpha,22-dihydroxycholesterol + NADP+ + H2O
-
?
24,25-epoxycholesterol + NADPH + H+ + O2
-
Mus musculus 7alpha,hydroxy-24,25-epoxycholesterol + NADP+ + H2O
-
?
24-hydroxycholesterol + NADPH + H+ + O2
-
Mus musculus 7alpha,24-dihydroxycholesterol + NADP+ + H2O
-
?
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 substrates in descending order of activity: cholest-5-ene-3beta,25-diol, cholest-5-ene-3beta,27-diol, 24,25-epoxycholesterol, 22-hydroxycholesterol, 24-hydroxycholesterol Mus musculus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
-
Mus musculus cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP7B1
-
Mus musculus
CYP7B1
-
Homo sapiens