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Literature summary for 1.14.14.24 extracted from

  • Yasuda, K.; Endo, M.; Ikushiro, S.; Kamakura, M.; Ohta, M.; Sakaki, T.
    UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1 (2013), Biochem. Biophys. Res. Commun., 434, 311-315.
    View publication on PubMed
Search for more literature for 1.14.14.24

Cloned(Commentary)

Cloned (Comment) Organism
functional recombinant expression of human CYP2R1 in Saccharomyces cerevisiae Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome CYP2R1 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
calciferol + O2 + [reduced NADPH-hemoprotein reductase] Homo sapiens enzyme CYP2R1 hydroxylates vitamin D2 at position C-25 position 25-hydroxy-vitamin D2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
calciol + O2 + [reduced NADPH-hemoprotein reductase] Homo sapiens enzyme CYP2R1 hydroxylates vitamin D3 at position C-25 position calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6VVX0 gene CYP2R1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calciferol + O2 + [reduced NADPH-hemoprotein reductase] enzyme CYP2R1 hydroxylates vitamin D2 at position C-25 position Homo sapiens 25-hydroxy-vitamin D2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
calciferol + O2 + [reduced NADPH-hemoprotein reductase] enzyme CYP2R1 hydroxylates vitamin D2 at position C-25 position Homo sapiens 25-hydroxyergocalciferol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
calciol + O2 + [reduced NADPH-hemoprotein reductase] enzyme CYP2R1 hydroxylates vitamin D3 at position C-25 position Homo sapiens calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP2R1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function CYP2R1 is a physiologically important vitamin D 25-hydroxylase. Vitamin D3 is initially converted to 25(OH)D3 in the liver, and then 25(OH)D 3 is converted to a functionally active form, namely 1alpha,25(OH)2D3, in the kidney. 1alpha,25(OH)2D3 plays essential roles in calcium and phosphate homeostasis, cell differentiation and immunology. Metabolic activation of vitamin D3 is performed by the hepatic vitamin D3 25-hydroxylase microsomal CYP2R1, and mitochondrial 1alpha-hydroxylase CYP27A1 Homo sapiens