Cloned (Comment) | Organism |
---|---|
expression in HEK 293 cell | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6VVW9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | CYP2R1 mRNA is abundant in the liver and testis | Mus musculus | - |
testis | CYP2R1 mRNA is abundant in the liver and testis | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
vitamin D3 + O2 + NADPH + H+ | - |
Mus musculus | 25-hydroxyvitamin D3 + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP2R1 | - |
Mus musculus |
cytochrome P450 2R1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | expression of CYP2R1 in HEK 293 cells leads to the transcriptional activation of the vitamin D receptor when either vitamin D2 or D3 is added to the medium. Co-expression of CYP2R1 with vitamin D 1-hydroxylase CYP27B1 elicits additive activation of vitamin D3, whereas co-expression with vitamin D 24-hydroxylase CYP24A1 causes inactivation | Mus musculus |