Cloned (Comment) | Organism |
---|---|
expression in Saccharomyces cerevisiae | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00045 | - |
vitamin D2 | pH 7.4, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | addition of NAD+ in presence of 1alpha-hydroxy-vitamin D2 to CYP2R1 induces a typical type I spectrum, indicating a change of the heme iron of CYP2R1 from a low-spin state to a high-spin state | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1alpha-hydroxy-vitamin D2 + O2 + [reduced NADPH-hemoprotein reductase] + H+ | - |
Homo sapiens | 1alpha,25-dihydroxy-vitamin D2 + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1alpha-hydroxy-vitamin D3 + O2 + [reduced NADPH-hemoprotein reductase] + H+ | - |
Homo sapiens | 1alpha,25-dihydroxy-vitamin D3 + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | CYP2R1 shows no detectable 1alpha-hydroxylation activity | Homo sapiens | ? | - |
? | |
vitamin D2 + O2 + NADPH + H+ | - |
Homo sapiens | 25-hydroxy-vitamin D2 + NADP+ + H2O | - |
? | |
vitamin D3 + O2 + NADPH + H+ | - |
Homo sapiens | 25-hydroxy-vitamin D3 + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP2R1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
vitamin D2 | pH 7.4, 37°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | addition of NAD+ in presence of 1alpha-hydroxy-vitamin D2 to CYP2R1 induces a typical type I spectrum, indicating a change of the heme iron of CYP2R1 from a low-spin state to a high-spin state | Homo sapiens |