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Literature summary for 1.14.14.24 extracted from

  • Rahmaniyan, M.; Patrick, K.; Bell, N.H.
    Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase (2005), Am. J. Physiol. Endocrinol. Metab., 288, E753-E760.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in insect cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
1alpha-hydroxyvitamin D3 pH 7.4, 37°C, 25-hydroxylation Rattus norvegicus
0.0042
-
1alpha-hydroxyvitamin D2 pH 7.4, 37°C, 24-hydroxylation Rattus norvegicus
0.0051
-
1alpha-hydroxyvitamin D3 pH 7.4, 37°C, 26-hydroxylation Rattus norvegicus
0.0058
-
1alpha-hydroxyvitamin D3 pH 7.4, 37°C, 24-hydroxylation Rattus norvegicus
0.018
-
1alpha-hydroxyvitamin D2 pH 7.4, 37°C, 25-hydroxylation Rattus norvegicus
0.018
-
1alpha-hydroxyvitamin D2 pH 7.4, 37°C, 26-hydroxylation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P08683 male-specific hepatic microsomal vitamin D 25-hydroxlase CYP2C11
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1alpha,25-dihydroxyvitamin D2 + O2 + [reduced NADPH-hemoprotein reductase] + H+
-
Rattus norvegicus 1alpha,25,26-trihydroxyvitamin D2 + [oxidized NADPHhemoprotein reductase] + H2O
-
?
1alpha,25-dihydroxyvitamin D3 + O2 + [reduced NADPH-hemoprotein reductase] + H+
-
Rattus norvegicus 1alpha,25,26-trihydroxyvitamin D3 + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
1alpha-hydroxyvitamin D2 + O2 + NADPH + H+
-
Rattus norvegicus 1alpha,25-dihydroxyvitamin D2 + NADP+ + H2O
-
?
1alpha-hydroxyvitamin D3 + O2 + NADPH + H+
-
Rattus norvegicus 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
?
additional information the descending order of 25-hydroxylation by CYP2C11 is 1-hydroxyvitamin D3, 1-hydroxyvitamin D2, vitamin D, vitamin D3. 24-Hydroxylation of 1alpha-hydroxyvitamin D3 is very low and does not occur with 1-alpha-hydroxyvitamin D2 Rattus norvegicus ?
-
?
vitamin D2 + O2 + NADPH + H+
-
Rattus norvegicus 25-hydroxyvitamin D2 + NADP+ + H2O
-
?
vitamin D3 + O2 + NADPH + H+
-
Rattus norvegicus 25-hydroxyvitamin D3 + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP2C11
-
Rattus norvegicus
Cytochrome P450 2C11
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus in male rats, hepatic microsomal CYP2C11 mRNA is decreased by 73% upon hypophysectomy down

General Information

General Information Comment Organism
physiological function in male rats, hypophysectomy reduces body weight by 40% and liver weight by 50%. 25-Hydroxylase activity is reduced by 64%, 24-hydroxylase activity is reduced by 52%, and hepatic microsomal CYP2C11 mRNA is decreased by 73% compared with the values of sham-operated animals Rattus norvegicus