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Literature summary for 1.14.14.23 extracted from

  • Chow, E.C.; Magomedova, L.; Quach, H.P.; Patel, R.; Durk, M.R.; Fan, J.; Maeng, H.J.; Irondi, K.; Anakk, S.; Moore, D.D.; Cummins, C.L.; Pang, K.S.
    Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol (2014), Gastroenterology, 146, 1048-1059.
    View publication on PubMed
Search for more literature for 1.14.14.23

Organism

Organism UniProt Comment Textmining
Homo sapiens P22680 gene CYP7A1
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Mus musculus Q64505 gene CYP7A1
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Mus musculus C57BL/6 Q64505 gene CYP7A1
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell enzyme expression analysis, increased levels of Cyp7a1/CYP7A1 mRNA in human hepatocytes treated with 1alpha,25-dihydroxyvitamin D3 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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hepatocyte
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 Homo sapiens
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hepatocyte
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 Mus musculus
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liver
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 Homo sapiens
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liver distribution of vitamin D receptor and enzyme proteins in the liver by immunostaining, overview Mus musculus
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additional information enzyme expression analysis in mice fed normal or Western diets for 3 weeks and then given intraperitoneal injections of vehicle (corn oil) or 1alpha,25-dihydroxyvitamin D3 in 4 doses of 0.0025 mg/kg, every other day. Increased levels of Cyp7a1/CYP7A1 mRNA in mouse hepatocytes treated with 1alpha,25-dihydroxyvitamin D3 Mus musculus
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Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
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 Homo sapiens
cholesterol 7alpha-hydroxylase
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 Mus musculus
CYP7A1
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 Homo sapiens
CYP7A1
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 Mus musculus

Expression

Organism Comment Expression
Homo sapiens in farnesoid X receptor-deficient and wild-type mice with hypercholesterolemia, injection of 1alpha,25-dihydroxyvitamin D3 consistently reduces levels of plasma and liver cholesterol and farnesoid X receptor small heterodimer partner Shp mRNA, and increases hepatic Cyp7a1 mRNA and protein. The transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), are essential for CYP7A1 expression up
Mus musculus in farnesoid X receptor-deficient and wild-type mice with hypercholesterolemia, injection of 1alpha,25-dihydroxyvitamin D3 consistently reduces levels of plasma and liver cholesterol and farnesoid X receptor small heterodimer partner, Shp, mRNA, and increases hepatic Cyp7a1 mRNA and protein. The transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), are essential for CYP7A1 expression up

General Information

General Information Comment Organism
metabolism bile acids such as chenodeoxycholic acid (CDCA) activate farnesoid X receptor FXR to increase transcription of small heterodimer partner SHP, an atypical nuclear receptor that lacks a DNA binding domain and represses CYP7A1 activation by suppression of transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), which are essential for CYP7A1 expression. A second negative feedback mechanism on CYP7A1 is found in the intestine, where activation of FXR induces fibroblast growth factor 15/19, a hormonal signaling molecule that represses CYP7A1 through interaction with the liver fibroblast growth factor receptor 4 via the c-Jun signaling pathway. Role for the vitamin D receptor on CYP7A1 regulation, overview Homo sapiens
metabolism bile acids such as chenodeoxycholic acid (CDCA) activate farnesoid X receptor FXR to increase transcription of small heterodimer partner SHP, an atypical nuclear receptor that lacks a DNA binding domain and represses CYP7A1 activation by suppression of transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), which are essential for CYP7A1 expression. A second negative feedback mechanism on CYP7A1 is found in the intestine, where activation of FXR induces fibroblast growth factor 15/19, a hormonal signaling molecule that represses CYP7A1 through interaction with the liver fibroblast growth factor receptor 4 via the c-Jun signaling pathway. Role for the vitamin D receptor on CYP7A1 regulation, overview Mus musculus
additional information activation of the vitamin D receptor represses hepatic SHP to increase levels of human CYP7A1 and reduce cholesterol Homo sapiens
additional information in farnesoid X receptor-deficient and wild-type mice with hypercholesterolemia, injection of 1alpha,25-dihydroxyvitamin D3 consistently reduces levels of plasma and liver cholesterol and farnesoid X receptor small heterodimer partner Shp mRNA, and increases hepatic Cyp7a1 mRNA and protein. Activation of the vitamin D receptor represses hepatic SHP to increase levels of mouse CYP7A1 and reduce cholesterol Mus musculus