Application | Comment | Organism |
---|---|---|
medicine | CYP7A1 overexpression in transgenic mice leads to marked activation of the steroid response element-binding protein 2-regulated cholesterol metabolic network and absence of bile acid repression of lipogenic gene expression in livers. Cyp7a1-tg mice show significantly elevated hepatic cholesterol synthesis rates, but reduced hepatic fatty acid synthesis rates, which is accompanied by increased 14C-glucose-derived acetyl-coenzyme A incorporation into sterols for fecal excret | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
Cyp7a1-tg mice overexpressing rat Cyp7a1 complementary DNA under an ApoE3 hepatic control region | Rattus norvegicus |
expressed in Mus musculus liver | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | P18125 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7alpha-hydroxylase | - |
Homo sapiens |
CYP7A1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | CYP7A1 overexpression in transgenic mice leads to marked activation of the steroid response element-binding protein 2-regulated cholesterol metabolic network and absence of bile acid repression of lipogenic gene expression in livers. Cyp7a1-tg mice show significantly elevated hepatic cholesterol synthesis rates, but reduced hepatic fatty acid synthesis rates, which is accompanied by increased 14C-glucose-derived acetyl-coenzyme A incorporation into sterols for fecal excret | Rattus norvegicus |
physiological function | CYP7A1 overexpression leads to marked activation of the steroid response elementbinding protein 2-regulated cholesterol metabolic network and absence of bile acid repression of lipogenic gene expression in livers | Homo sapiens |