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Literature summary for 1.14.14.23 extracted from

  • Li, T.; Francl, J.M.; Boehme, S.; Chiang, J.Y.
    Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice (2013), Hepatology, 58, 1111-1121.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine CYP7A1 overexpression in transgenic mice leads to marked activation of the steroid response element-binding protein 2-regulated cholesterol metabolic network and absence of bile acid repression of lipogenic gene expression in livers. Cyp7a1-tg mice show significantly elevated hepatic cholesterol synthesis rates, but reduced hepatic fatty acid synthesis rates, which is accompanied by increased 14C-glucose-derived acetyl-coenzyme A incorporation into sterols for fecal excret Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
Cyp7a1-tg mice overexpressing rat Cyp7a1 complementary DNA under an ApoE3 hepatic control region Rattus norvegicus
expressed in Mus musculus liver Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus P18125
-
-

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
Homo sapiens
CYP7A1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
physiological function CYP7A1 overexpression in transgenic mice leads to marked activation of the steroid response element-binding protein 2-regulated cholesterol metabolic network and absence of bile acid repression of lipogenic gene expression in livers. Cyp7a1-tg mice show significantly elevated hepatic cholesterol synthesis rates, but reduced hepatic fatty acid synthesis rates, which is accompanied by increased 14C-glucose-derived acetyl-coenzyme A incorporation into sterols for fecal excret Rattus norvegicus
physiological function CYP7A1 overexpression leads to marked activation of the steroid response elementbinding protein 2-regulated cholesterol metabolic network and absence of bile acid repression of lipogenic gene expression in livers Homo sapiens