Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64505 | wild-type and homozygous Clock mutant mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | expression profile of the Cyp7a transcript in wild-type mice shows a strong circadian rhythm in both the 12L:12D light-dark cycle and constant darkness. In Clock/Clock mutant mice expression profile of the Cyp7a transcript also exhibits a circadian rhythm at an enhanced level with a lower amplitude, although its protein level becomes arrhythmic at a high level. Active CLOCK is essential for the robust circadian expression of Cyp7a. Clock-controlled genes - DBP, DEC2, and REV-ERBalpha/beta are direct regulators required for the robust circadian rhythm of Cyp7a. The circadian rhythm of Cyp7a is regulated by multiple transcription factors, including DBP, REV-ERBalpha/beta, LXRalpha, HNF4alpha DEC2, E4BP4, and PPARalpha | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7alpha-hydroxylase | - |
Mus musculus |
CYP7A | - |
Mus musculus |