Cloned (Comment) | Organism |
---|---|
gene CYP7A1, transient expression in Hep-G2 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | mechanism of insulin regulation of CYP7A1 gene expression in human hepatocytes, physiological concentrations of insulin rapidly stimulate CYP7A1 mRNA expression in primary human hepatocytes but inhibit CYP7A1 expression after extended treatment, forkhead box O1 and sterol regulatory element-binding protein 1c are involved, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | insulin, forkhead box O1, and sterol regulatory element-binding protein 1c are involved in regulation of expression of gene CYP7A1, genetic mechanism, overview | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22680 | gene CYP7A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary, CYP7A1 expression analysis in absence or presence of isnulin | Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | insulin, forkhead box O1, and sterol regulatory element-binding protein 1c are involved in regulation of expression of gene CYP7A1, genetic mechanism, overview | Homo sapiens | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7alpha-hydroxylase | - |
Homo sapiens |
CYP7A1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |