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Literature summary for 1.14.14.23 extracted from

  • Wang, J.; Olin, M.; Rozell, B.; Bjoerkhem, I.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
    Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse (2007), Histochem. Cell Biol., 127, 253-261.
    View publication on PubMed
Search for more literature for 1.14.14.23

Cloned(Commentary)

Cloned (Comment) Organism
Cyp7a1 expression pattern in wild-type and Cyp8b1 null mice livers, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 wild-type C57Bl/6 and male Cyp8b1 knockout mice on a mixed 129Sv/Ev-C57Bl/6 background
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Mus musculus
-
liver Cyp7a1 expression pattern in wild-type and Cyp8b1 null mice livers, Cyp7a1 expression in wild type mice shows a zonal distribution pattern, Cyp8b1 knockout mice show increased expression of Cyp7a1, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
 Mus musculus
CYP7A1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus