Cloned (Comment) | Organism |
---|---|
gene CYP7A1, DNA sequence determination and analysis, phylogenetic tree, expression analysis and regulation, overview | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, molecular mechanisms underlying CYP7A1 inhibition, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression | Gallus gallus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Gallus gallus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Gallus gallus | the gene encoding CYP7A1 is tightly regulated in order to control intrahepatic cholesterol and bile acid levels, ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, bile acids regulate CYP7A1 via small heterodimer partner and liver receptor homolog-1, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression, overview | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | Q5ILH2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Gallus gallus | - |
liver | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Gallus gallus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | the gene encoding CYP7A1 is tightly regulated in order to control intrahepatic cholesterol and bile acid levels, ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, bile acids regulate CYP7A1 via small heterodimer partner and liver receptor homolog-1, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression, overview | Gallus gallus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7alpha-hydroxylase | - |
Gallus gallus |
CYP7A1 | - |
Gallus gallus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Gallus gallus |