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Literature summary for 1.14.14.23 extracted from

  • Handschin, C.; Gnerre, C.; Fraser, D.J.; Martinez-Jimenez, C.; Jover, R.; Meyer, U.A.
    Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids (2005), Arch. Biochem. Biophys., 434, 75-85.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP7A1, DNA sequence determination and analysis, phylogenetic tree, expression analysis and regulation, overview Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
additional information ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, molecular mechanisms underlying CYP7A1 inhibition, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Gallus gallus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Gallus gallus the gene encoding CYP7A1 is tightly regulated in order to control intrahepatic cholesterol and bile acid levels, ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, bile acids regulate CYP7A1 via small heterodimer partner and liver receptor homolog-1, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression, overview 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus Q5ILH2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Gallus gallus
-
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
Gallus gallus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 the gene encoding CYP7A1 is tightly regulated in order to control intrahepatic cholesterol and bile acid levels, ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, bile acids regulate CYP7A1 via small heterodimer partner and liver receptor homolog-1, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression, overview Gallus gallus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
Gallus gallus
CYP7A1
-
Gallus gallus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Gallus gallus