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Literature summary for 1.14.14.23 extracted from
- Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats (2005), Ann. Clin. Lab. Sci., 35, 323-328.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | the enzyme is involved in bile acid biosynthesis in liver | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | enzyme activity during liver regeneration after hepatectomy, 7alpha-hydroxylase activities recover after day 3 and are not reduced on days 3, 5, or 7 compared to those of sham-operated rats | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme activity during liver regeneration after hepatectomy, 7alpha-hydroxylase activities recover after day 3 and are not reduced on days 3, 5, or 7 compared to those of sham-operated rats | Rattus norvegicus |
| 0.000022 | - |
day 1 after hepatectomy | Rattus norvegicus |
| 0.000048 | - |
day 1 after sham operation | Rattus norvegicus |
| 0.000058 | - |
day 3 after sham operation | Rattus norvegicus |
| 0.000065 | - |
day 3 after hepatectomy | Rattus norvegicus |
| 0.000069 | - |
day 7 after hepatectomy | Rattus norvegicus |
| 0.000075 | - |
day 7 after sham operation | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in bile acid biosynthesis in liver | Rattus norvegicus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 7alpha-hydroxylase | - |
Rattus norvegicus |
| cholesterol 7alpha-hydroxylase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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