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Literature summary for 1.14.14.19 extracted from

  • Estrada, D.F.; Skinner, A.L.; Laurence, J.S.; Scott, E.E.
    Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5 (2014), J. Biol. Chem., 289, 14310-14320.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.19

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
abiraterone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05093
-
-

Purification (Commentary)

Purification (Comment) Organism
metal affinity and ion exchange chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP17A1
-
 Homo sapiens
cytochrome P450 17A1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the bifunctional enzyme is responsible for pregnenolone C17 hydroxylation, followed by a 17,20-lyase reaction to produce dehydroepiandrosterone, the key intermediate in human synthesis of androgen and estrogen sex steroids Homo sapiens